Initiator proteins direct the assembly of DNA synthesis enzymes at chromosomal sites in a highly regulated manner. In bacteria, the initiator DnaA cooperatively oligomerizes at the site of replication ...

Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the ...

In many sexually dimorphic species, a mechanism is required to ensure equivalent levels of gene expression from the sex chromosomes. In mammals, such dosage compensation is achieved by X-chromosome ...