Scientists are uncovering a deeper layer of DNA biology—where its shape, stiffness, and 3D organization are just as important as its sequence. New tools are mapping how replication starts, how damage ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

DNA’s elegant double helix isn’t just beautiful—it’s a masterclass in precision engineering. From base pairing to semi-conservative replication, every step ensures life’s blueprint is copied ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

DNA replication is a tightly controlled process that copies the genetic code, allowing its instructions to be conveyed from one generation of cells to the next. In diseases like cancer, these ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

It did not take long after the discovery of X-rays in the 1890s for scientists to begin exploring the harmful effects of ...